I am serving as the co-investigator/collaborator, and providing bioinformatics supports for these projects:
Active
Title: Overcoming tumor-intrinsic mechanisms of immune evasion to boost systemic response to radiotherapy
- Major Goals: Elucidate the molecular and cellular mechanisms of B7-H3 induced CD8 T cell dysfunction, and dissect the mechanisms of systemic immunosuppression mediated by B7-H3+ tdEVs in response to radiotherapy.
- Project Number: R01 CA278908
- Source of Support: NIH/NCI
- Start and End Date: 2024 - 2029
- PI: Lucien-Matteoni, F
Title: Mechanism and therapeutic targeting of castration resistance in SPOP-mutated prostate cancer
- Major Goals: Major Goals: The major goals of this project are to determine the molecular mechanisms by which SPOP mutation cooperates with aberrantly activated MAPK pathway to drive aberrant activation of AR and castration-resistant progression of prostate cancer and define new strategies for the effective treatment of SPOP-mutated castration-resistant prostate cancer.
- Project Number: R01 CA285345-01 (pending)
- Source of Support: NIH/NCI
- Start and End Date: 2023 - 2028
- PI: Huang, H
Title: Determine the Microphthalmia Transcription Factor (MITF)-regulated cell rewiring mechanisms in lethal prostate cancer
- Major Goals: Determine the role of Microphthalmia Transcription Factor regulated cell rewiring mechanisms in lethal prostate cancer
- Project Number: R01CA 271486-1
- Source of Support: NIH/NCI
- Start and End Date: 2022 - 2026
- PI: Domingo Domenech, J.
Title: Alliance Statistics and Data Management Center Grant
- Major Goals: The major goal of this project is to serve as the Statistics and Data Management Center for all research conducted by the Alliance for Clinical Trials in Oncology, which is a multi-institution, multi-specialty oncology research organization.
- Project Number: U10CA 180882-8
- Source of Support: NIH/NCI
- Start and End Date: 2019 - 2025
- PI: Mandrekar S.
Title: Spatially-resolved protein and transcriptome mapping of senescent cells
- Major Goals: The primary goal of this project is to develop and optimize iterative and complementary high-dimensional multimarker imaging and spatial transcriptomic methods to phenotype senescent cells in aged mouse tissues.
- Project Number: 1UG3CA 275669-01
- Source of Support: NIH
- Start and End Date: 2022 - 2026
- PI: Schafer M.
Title: Cooperativity of TMPRSS2-ERG fusion with p53 inactivation in prostate cancer pathogenesis
- Major Goals: The primary goal of this project is to determine the molecular mechanism of TMPRSS2-ERG fusion gene and p53 inactivation in prostate cancer development and progression.
- Project Number: R01CA 271486-1
- Source of Support: NIH/NCI
- Start and End Date: 2023 - 2027
- PI: Huang H.
Title: Role of proinflammatory cytokine-induced AR degradation in castration-resistant prostate cancer
- Major Goals: The primary goal of this project is to determine the molecular mechanism and functional importance of IKK-mediated AR degradation in response to the inflammatory cytokine in PCa cells.
- Project Number: RO1CA 130908-12
- Source of Support: NIH/NCI
- Start and End Date: 2017 - 2023
- PI: Huang H.
Title: Mechanism and role of aberrant AR activity in castration-resistant prostate cancer
- Major Goals: The goal of this project is to elucidate the aberrant AR activity during prostate cancer progression and the relationship with therapeutic resistance.
- Project Number: RO1CA 203849-4
- Source of Support: NIH/NCI
- Start and End Date: 2018 - 2023
- PI: Huang H.
Title: Understanding the interactions between germline and somatic alterations in the pathogenesis of gliomas
- Major Goals: The goals of this project is to evaluate the clinical relevance of combined germline and somatic alterations associated with IDH-mutant glioma and characterize the functional implication of the known and newly identified glioma germline variants in the context of IDH-mutant glioma.
- Project Number: RO1CA 230712-4
- Source of Support: NIH/NCI
- Start and End Date: 2018 - 2023
- PI: Jenkins R.
Title: Epigenetic Mechanisms Underlying Hepatitis C-Induced Hepatocarcinogenesis
- Major Goals: The goal of this project is to determine how acute and chronic HCV infection deregulates DNA methylation and hydroxymethylation patterns to promote hepatitis, fibrosis, liver disease, and eventual progression to hepatocellular cancer. The project also seeks to identify epigenetic markers of this progression.
- Project Number: R01DK 110024-4
- Source of Support: NIH/NCI
- Start and End Date: 2017 - 2022
- PI: Robertson K.
Title: Discovery and validation of non-invasive epigenetic biomarkers for AATD liver disease
- Major Goals: Identification of predictive DNA methylation markers for Alpha-1 antitrypsin deficiency liver disease.
- Project Number: 682189
- Source of Support: Alpha 1 foundation
- Start and End Date: 2020 - 2022
- PI: Robertson K.
Title: Identify the genomic biomarkers of migraine
- Major Goals: The goal of this project is to identify genomic variants and develop polygenic scores to predict migraine patients’ response to Atenolol and Topiramate treatment.
- Project Number: N/A
- Source of Support: Benefactor
- Start and End Date: 2019 - 2024
- PI: Cutrer M.
Title: Single-cell transcriptional and epigenomic dissection to identify therapeutic targets for ALS and FTD.
- Major Goals: (1) Profile the transcriptional and epigenomic alterations of FTLD and ALS patients at single-cell resolution using post-mortem brain samples. (2) Study the link between genetic, epigenomic, transcriptional, and cellular signatures of FTLD and ALS, and to study the common and distinct genes and pathways altered in each, to predict new therapeutic targets.
- Project Number: R01AG067151
- Source of Support: NIH/NIA
- Start and End Date: 2021 - 2025
- PI: Belzil/Kellis
Title: Epigenetic Heterogeneity as a Driver of Liver Disease and Cancer
- Major Goals: The goal of this project is to elucidate the functional impacts of DNA methylation heterogeneities in liver disease and cancer.
- Project Number: R01AA 27179
- Source of Support: National Institute on Alcohol Abuse and Alcoholism
- Start and End Date: 2018 - 2023
- PI: Robertson K.
Completed
Title: The role of EZH2 in PTEN-deficient prostate cancer pathogenesis and therapy
- Project Number: W81XWH-14-1-0486
- Source of Support: U.S. Department of Defense
- Start and End Date: 2014 - 2017
- PI: Huang H.
Title: Targeting aberrant AR-FL and AR-V expression and activity to overcome therapy resistance in metastatic castration-resistant prostate cancer
- Project Number: N/A
- Source of Support: Prostate Cancer Foundation (PCF)
- Start and End Date: 2014 - 2017
- PI: Huang H.
Title: Mechanism of Action and Disease Relevance of Androgen Receptor-Bound Enhancer RNAs (AR-eRNAs) in Prostate Cancer
- Project Number: N/A
- Source of Support: Mayo Cilnic
- Start and End Date: 2015 - 2017
- PI: Huang H.
Title: Role of RUNX2 in prostate cancer intratumoral androgen synthesis and progression
- Project Number: R01 CA193239-5
- Source of Support: NIH/NCI
- Start and End Date: 2015 - 2021
- PI: Huang H.
Title: Role of FOXO1 Inactivation in Prostate Tumorigenesis
- Project Number: R01 CA134514-11
- Source of Support: NIH/NCI
- Start and End Date: 2015 - 2021
- PI: Huang H.
Title: Epigenetic Mechanisms Underlying Hepatitis C-Induced Hepatocarcinogenesis
- Project Number: R01DK 110024-4
- Source of Support: NIH/NIDDK
- Start and End Date: 2017 - 2021
- PI: Robertson K.
Title: Deciphering the interplay between H3K36 and DNA methylation in renal cancer
- Project Number: R01 CA224917-01
- Source of Support: NIH/NCI
- Start and End Date: 2017 - 2021
- PI: Robertson K.